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This is book number 10 in the Last Man series.
Featured in THE NEW YORK TIMES and on NPR, Y: THE LAST MAN is the gripping saga of Yorick Brown, an unemployed and unmotivated slacker who discovers he is the only male left in the world after a plague of unknown origin instantly kills every mammal with a Y chromosome. Accompanied by his mischievous monkey, Ampersand, and the mysterious Agent 355, Yorick embarks on a transcontinental journey to find his long-lost girlfriend and discover why he is the last man on earth.
Yorick Brown's long journey through an Earth populated only by women comes to a dramatic, unexpected conclusion in this final volume. Collects issues #55-60 of Brian K. Vaughan and Pia Guerra's award-winning Vertigo series.